Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

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Data flows left to right. Each stage reads input, does its work, writes output. There's no pipe reader to acquire, no controller lock to manage. If a downstream stage is slow, upstream stages naturally slow down as well. Backpressure is implicit in the model, not a separate mechanism to learn (or ignore).